Tangential Flow Filters (SepraPor^®)

Meissner SepraPor® tangential flow filters are hollow fiber membrane devices designed for tangential flow filtration in biopharmaceutical processes. They are used in applications that require efficient cell retention, concentration, perfusion, and harvest while helping maintain gentle processing conditions for sensitive cell cultures.

SepraPor® tangential flow filters are used for cell culture perfusion, bacterial cell concentration, mammalian cell concentration, yeast concentration, and high-productivity harvest processes. They are well suited for biopharmaceutical applications where continuous processing, cell retention, and efficient volumetric control are important.

SepraPor® tangential flow filters are available in capsule and cartridge formats. Capsule formats support single-use and ready-to-deploy applications, while cartridge formats are designed for use in compatible stainless steel housings for reusable process setups.

SepraPor® capsules are typically used in single-use or pre-assembled process configurations where fast installation and simplified handling are important. SepraPor® cartridges are used in reusable housing-based systems and are often selected when a stainless steel TFF setup is preferred.

SepraPor® microporous hollow fiber membranes are available in multiple porosity ratings, including 0.1 µm, 0.2 µm, and 0.45 µm options. These pore sizes support a range of cell retention and tangential flow process requirements depending on the target application.

SepraPor® filters are available in a broad range of sizes for use from laboratory-scale development through production-scale processing. This allows users to scale tangential flow applications while maintaining the same core hollow fiber membrane platform across different filter sizes.

SepraPor® filters support multiple sterilization approaches depending on the format selected. Capsule configurations can support single-use sterile deployment, while cartridge configurations are used in systems designed for sterilization methods such as autoclaving or steam-in-place, depending on the process setup.

The right SepraPor® filter size depends on your recirculation flow rate, target shear conditions, process volume, and cell culture requirements. In general, sizing should align with the desired balance between throughput, gentle processing, and efficient cell retention across the intended scale.

The SepraPor® hollow fiber design supports high surface area in a compact format, efficient tangential flow performance, and low-shear processing conditions that are well suited for sensitive cells. It is designed to help users achieve effective cell retention, strong throughput, and flexible deployment in both single-use and reusable system formats.