Tangential Flow Capsule Filters

Tangential Flow Capsule Filters are filtration devices designed for tangential flow filtration (TFF) processes. They consist of a capsule format housing membrane filters that allow for scalable filtration from laboratory to full production scale. These filters operate by directing fluid flow tangentially across the membrane surface, reducing fouling and enabling efficient separation and concentration of biomolecules.

Tangential Flow Capsule Filters are used primarily in biopharmaceutical manufacturing for applications such as cell harvesting, clarification, concentration, and diafiltration of proteins, antibodies, and other biomolecules. They support processes requiring sterile filtration and are suitable for both upstream and downstream processing steps in bioprocess workflows.

SepraPor® Tangential Flow Capsule Filters are available in multiple configurations to accommodate different process scales, ranging from laboratory-scale units to full-scale production capsules. Specific membrane area, pore size, and material options vary to meet process requirements, enabling scalability and compatibility with diverse bioprocessing needs.

Tangential Flow Capsule Filters provide scalable filtration solutions with a capsule design that facilitates easy integration and handling. Their tangential flow operation minimizes membrane fouling and extends filter life. The SepraPor® membrane technology offers consistent performance and compatibility with a range of biopharmaceutical fluids, supporting sterile and single-use processing environments.

Tangential Flow Capsule Filters are designed for seamless integration into bioprocess workflows, compatible with standard single-use fluid path components and tubing. Their capsule format supports quick connection and disconnection, facilitating integration with upstream and downstream equipment such as pumps, tubing assemblies, and process monitoring devices within single-use or hybrid systems.

Yes, Tangential Flow Capsule Filters are suitable for regulated biopharmaceutical manufacturing. They are manufactured under quality systems compliant with industry standards, ensuring traceability and reproducibility. The filters support sterile processing and are compatible with single-use systems, reducing contamination risk and meeting regulatory requirements for bioprocess filtration.

Tangential Flow Capsule Filters can be customized to some extent to meet specific process requirements. Customization options may include membrane material selection, pore size, membrane area, and capsule configuration. These adaptations allow optimization for particular biomolecules, process volumes, and operational parameters within biopharmaceutical manufacturing workflows.

Complementary products used alongside Tangential Flow Capsule Filters include upstream single-use components such as Single-Use Systems, M-Flex® TPE Tubing, and BioFlex® Fluid Path Assemblies. Downstream, integration with process monitoring and control devices like the SGT (Single-Use Gauge Tee) is common. These products facilitate fluid transfer, connection, and monitoring within bioprocess workflows.