Tangential Flow Hollow Fiber Cartridges

Tangential Flow Hollow Fiber Cartridges, specifically the SepraPor® XFM series, are filtration cartridges containing polysulfone hollow fibers designed for tangential flow filtration. They are used in microfiltration and ultrafiltration applications, available in various lengths and diameters for scalable biopharmaceutical processing. These cartridges retrofit stainless steel housings and support steam-in-place (SIP) or autoclave sterilization, ensuring flexibility and sterility in manufacturing.

SepraPor® XFM hollow fiber cartridges are ideal for biopharmaceutical applications such as bacterial, mammalian, and yeast cell concentration, high productivity harvest, and continuous cell culture perfusion. They are also used in ultrafiltration processes including diafiltration and plasmid DNA purification, supporting diverse upstream and downstream bioprocessing needs.

SepraPor® XFM cartridges come in diameters of 2″, 3″, and 4″ with fluid path lengths of 12″ or 24″ and effective filtration areas ranging from 4.3 ft² (0.4 m²) to 45.2 ft² (4.2 m²). Hollow fibers have 1.0 mm inner diameter and 1.5 mm outer diameter. Retention ratings vary from 0.4 µm down to 10 kDa molecular weight cutoffs, with maximum operating pressures up to 65 psi and temperatures up to 50°C for short-term use.

SepraPor® cartridges feature discrete retention ratings with narrow pore size distributions, ensuring unambiguous filter selection and consistent performance. They use a novel 3 Mw marker MWCO assignment for ultrafiltration membranes, have low fiber asymmetry for repeatable results, and are integrity tested individually. Their compatibility with SIP and autoclave sterilization enhances flexibility in biopharmaceutical manufacturing.

Yes, SepraPor® XFM cartridges are designed for biopharmaceutical manufacturing with quality assurance including Certificates of Conformance and lot-to-lot consistency verified by bubble point and flux analysis. They support sterilization methods like steam-in-place (SIP) and autoclaving, meeting stringent process control and regulatory requirements.

Common complementary products include Single-Use Systems, M-Flex® TPE Tubing, M-Sil™ Braid Reinforced Silicone Tubing, BioLink® Modular Overmolding Technology, and SGT (Single-Use Gauge Tee), supporting upstream and downstream bioprocess workflows.