Single use aliquoting systems | Meissner Corporation

Single-Use Automation Automated Aliquoting Automated Filtration/PUPSIT

Automated Aliquoting System (AAS)

Standardized, Automated Aliquoting for Critical Single-Use Workflows

Manual aliquoting, dispensing bulk drug substance or intermediate product into smaller single-use containers, remains one of the most operator-dependent steps in biopharmaceutical manufacturing. Every valve turn, weight check, and container swap is a chance for variability to enter the batch record. Meissner’s Automated Aliquoting System (AAS) standardizes this step, so consistency and accuracy are ensured and properly logged.

The challenge with manual aliquoting

Manual aliquoting introduces the same categories of risk regulators have flagged across aseptic processing generally: inconsistent technique between operators, extended intervention time in classified areas, and a training burden that scales with every new product or container format. As batch counts and product variety increase, manual aliquoting becomes a bottleneck as well as a risk.

What AAS does

The AAS automates the transfer of bulk product into final single-use containers, whether bottles, bags, or other primary packaging formats, replacing manual weighing, valve operation, and container handling with a repeatable, recipe-driven process and accurate batch records.

Key benefits

• Consistent fill accuracy across operators, shifts, and batches
• Reduced operator intervention in classified (Grade A/B) areas
• Faster changeover between container formats and batch sizes
• Compatibility with Meissner’s existing single-use fluid path, including TepoFlex^® biocontainers, FlexFill^® transfer assemblies, M-Sil^® tubing, and UltraClamp^® connections
• Electronic records supporting review-by-exception release workflows

Supporting Annex 1’s contamination control expectations

While EU GMP Annex 1 doesn’t name aliquoting specifically, its core principles apply directly to minimizing direct human intervention in Grade A operations, maintaining a documented Contamination Control Strategy (CCS) across every critical step. Using automation and robotics where they can remove operator-dependent risk, AAS is designed around those same principles, extending the standardization and control Annex 1 already expects for PUPSIT and filtration to the aliquoting step as well.

Built on Meissner’s single-use systems expertise

The AAS is designed to integrate directly with Meissner’s existing single-use portfolio, so standardizing aliquoting doesn’t mean redesigning the fluid path around it.