Better Characterized Ultrafiltration Membranes to Improve Biomanufacturing

Biotherapies are rapidly expanding, placing increased scrutiny on the performance and reliability of purification methods in biomanufacturing. At a recent Bioprocess International Conference and highlighted in a Genetic Engineering News (GEN), Meissner detailed a shift from single-marker membrane characterization to a continuum-based approach using at least three polymer molecular weight markers, resulting in significantly improved lot-to-lot consistency for ultrafiltration membranes. In a cell and gene therapy case study, Meissner’s SepraPor® hollow fiber membranes demonstrated a 40% reduction in processing time, greater than 98% product recovery and purity, and 25% lower buffer consumption compared to conventional cassettes—delivering both reproducibility and operational efficiency for advanced therapeutic workflows. Read Genetic Engineering News’ (GEN) article or watch the video presentation below.