Meissner/FujiFilm’s ATF video presentation at INTERPHEX NY

Alternating tangential flow (ATF) has been widely adopted as a method of continuous cell culture, with potential benefits of reduced fouling and improving sieving in upstream N-1 and production bioreactor processes. ATF utilizes a diaphragm pump to push the process fluid across the membrane surface in alternating directions. The bi-directional sweeping effect can reduce fouling and improve filter longevity during cell culture. The cell line, cell culture media, and filter membranes also greatly influence the performance of a perfusion run, and process parameters should be optimized to the properties and composition of those elements to maximize performance and intensify upstream processes. The renewed interest in perfusion cell culture technologies for continuous production of therapeutic recombinant proteins has led to the development of a cell culture media that can support high cell densities at 1 vessel volume per day, utilizing a CHO DG44 cell line.

Explore the ATF video presentation below:

Fluid Thoughts

Fluid Thoughts Form

This field is for validation purposes and should be left unchanged.
I would like to receive email notifications regarding new product announcements and industry events.