FlexGro^® Rocker Style Biocontainers

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FlexGro®

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industry experts.

FlexGro®

Single-Use biocontainers for use in rocker-style bioreactors

FlexGro^® single-use rocker-style biocontainer assemblies are ideal for various cell culture applications. FlexGro^® biocontainers are available in up to 50 L (or a maximum of 25 L operating volume). Each FlexGro^® assembly is supplied sterile (gamma-irradiated to ensure an SAL of 10^-6 substantiated according to ISO 11137 methodology).

FlexGro^® rocker style biocontainers are available in Meissner’s ultraclean TepoFlex^® PE multi-layer film as well as FluoroFlex^® PVDF multi-layer film. TepoFlex^® polyethylene film provides a low extractables and leachables profile with the industry’s highest combined gas and water vapor barrier. TepoFlex^® is the ideal choice for cell cultivation in production of vaccines and monoclonal antibodies, including suspension (e.g. CHO, 293) and microcarrier culture (e.g. MDCK, BHK, Vero). FlexGro^® biocontainers manufactured with TepoFlex^® film have been qualified for cell culture by means of a leachables study targeting antioxidants and their radiolytic and oxidative degradation products, mitigating the risk of cellular inhibition resulting from such degradation products.

FlexGro^® rocker style biocontainer assemblies can be easily customized to incorporate customer defined connections, tubing, and port options. Our applications engineering team has the expertise to provide designs that optimize the application requirements.

FlexGro^® rocker-based biocontainer assemblies can be used in environments from 0 ºC to 50 ºC.

Frequently Asked Questions

What are FlexGro® Rocker Style Biocontainers?

FlexGro® Rocker Style Biocontainers are single-use biocontainer assemblies designed for use in rocker-style bioreactors. They are intended for cell culture applications that require controlled mixing and disposable fluid-contact surfaces in biopharmaceutical processing.

What are FlexGro® biocontainers used for?

FlexGro® biocontainers are used for cell culture in rocker-style bioreactor workflows, including applications where users need a single-use format for cultivation, mixing, and process flexibility. They are designed for biopharmaceutical processes that benefit from disposable biocontainer systems.

What size FlexGro® biocontainers are available?

FlexGro® biocontainers are available in sizes up to 50 L, with a maximum operating volume of 25 L. This makes them well suited for development-scale and selected production-support cell culture applications in rocker-style systems.

Are FlexGro® biocontainers supplied sterile?

Yes. FlexGro® biocontainer assemblies are supplied sterile and are gamma-irradiated to support sterility assurance for single-use deployment in critical cell culture applications.

What film options are available for FlexGro® biocontainers?

FlexGro® biocontainers are available in Meissner’s TepoFlex® PE multi-layer film and FluoroFlex® PVDF multi-layer film. These film options allow users to choose a biocontainer platform that best matches their process and material requirements.

Why choose TepoFlex® film for FlexGro® biocontainers?

TepoFlex® film is positioned for applications that require low extractables and leachables and strong barrier performance. Meissner highlights it as a suitable choice for cell cultivation in the production of vaccines and monoclonal antibodies.

What types of cell culture can FlexGro® biocontainers support?

FlexGro® biocontainers are intended for a variety of cell culture applications. Meissner specifically identifies their use for suspension culture and microcarrier culture workflows in biopharmaceutical processing.

Are FlexGro® biocontainers suitable for suspension and microcarrier culture?

Yes. Meissner specifically notes FlexGro® biocontainers with TepoFlex® film as suitable for suspension cultures, such as CHO and 293 cells, and microcarrier cultures, such as MDCK, BHK, and Vero cells.

What qualification support is available for FlexGro® biocontainers?

Meissner states that FlexGro® biocontainers made with TepoFlex® film have been qualified for cell culture through a leachables study focused on antioxidants and related degradation products. This is intended to help mitigate the risk of cellular inhibition from those compounds.

Why choose FlexGro® for rocker-style bioreactor applications?

FlexGro® biocontainers are designed for users who need a sterile, single-use biocontainer for rocker-style cell culture processes. Their compatibility with multiple film platforms, support for common cell culture modes, and availability in practical rocker-scale volumes make them a flexible option for biopharmaceutical applications.