50 mm Critical Small Scale Filter Device
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50 mm Critical Small Scale Filter Device
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industry experts.
50 mm Critical Small Scale Filter Device
Ideal filters for removal of microorganisms and particulates from critical small batch liquid volumes from 50 mL to 2 L, and air and gas applications.
Meissner’s 50 mm critical small scale filtration device portfolio, or CB filter model line, delivers excellent performance in venting applications. However, by expanding the media options available in the 50 mm filter size to include a host of both hydrophobic and hydrophilic membranes, and Meissner’s unique gradient density prefilter media, the ideal applications for this filter device have been greatly expanded. For critical liquid or air/gas applications, we offer membrane options including hydrophilic PVDF and hydrophobic PVDF, hydrophilic PES, and hydrophobic PTFE. Our entire portfolio of 50 mm filter devices scales effortlessly into our mini capsule filters, medium capsule filters, standard capsule filters, and large capsule portfolios. Our 50 mm filter devices use the identical materials of construction as our entire capsule filter portfolio to ensure streamlined scaling without requalification or revalidation concerns.
While these filters have traditionally been referred to as “vent filters” or “50 mm filters,” Meissner’s CB product portfolio has been optimized for use in critical small scale or small volume filtration applications, delivering the same high quality, high performance, fully supported solution as larger scale filters common to typical process scale applications. Meissner recognizes that this is required for small batch and point of use filtration applications. Each filter is available 100% integrity tested and individually serialized to offer unparalleled traceability at this scale. Multiple process connection options, including hose barb and sanitary flange fittings, vent and filling bell options deliver maximum flexibility to allow this filter portfolio to cater to specific process needs.
Meissner’s CB filter portfolio is ideal for filtering small scale liquid volumes from 50 mL to 2 L. Applications for both liquids and gases include sterile filtration, sterile venting, sample preparation, process development studies, filterability testing, product compatibility and recovery trials, process screening and scaling, and prefiltration and clarification. Since the materials of construction of these filter devices is identical to our larger capsule filters, the scale-up of a process is seamless as clients transition to larger process volumes. The 50 mm filters are available sterile (gamma irradiated), or non-sterile, and also can be integrated into our One-Touch® portfolio of single-use processing solutions.
Our Steridyne® capsule filters are an industry preferred option for single-use bioreactor venting applications to maintain a closed system. The Steridyne® CB filter device offers the same level of high performance for smaller single-use and multi-use bioreactor venting with the Ultradyne® filter option being available for multi-use bioreactor applications, as well.
Filter Media Options
Membrane Filters for Liquid (Hydrophilic)
Microfiber Media Filters
Membrane Filters for Air/Gas (Hydrophobic)
Additional Filter Configurations
Frequently Asked Questions
What is 50 mm Critical Small Scale Filter Device?
The 50 mm Critical Small Scale Filter Device is a filtration component designed for small-volume venting, gas, and solvent filtration. It features membrane materials such as PVDF or PTFE, suitable for critical filtration applications in biopharmaceutical processes requiring sterile venting or gas filtration at a 50 mm scale.
What applications is 50 mm Critical Small Scale Filter Device used for?
This filter device is used primarily in small-volume venting applications, gas filtration, and solvent filtration within biopharmaceutical manufacturing. It is suitable for processes requiring critical filtration to maintain sterility and purity during gas exchange or venting of bioreactors, single-use systems, and other controlled environments.
- Sterile filtration of liquids
- Sterile filtration of gases (including venting of carboys, filling vessels, fermentation tanks, bioreactors, small product or intermediate tanks, degassing, and sterile purging of culture vessels)
- Sample preparation
- Filterability testing
- Product compatibility and recovery trials
- Process screening and scaling
- Prefiltration
- Clarification
- Sterile gas delivery to instruments, incubators, and culture vessels
- Protection of laboratory personnel from vacuum pump exhaust contaminants
- Protecting pump components from liquid damage by using between a pump and receiving vessel
- Filtering chromatography solutions
- Filtering reagents
What specifications or sizes are available for 50 mm Critical Small Scale Filter Device?
The device is available with a 50 mm diameter membrane area and offers membrane options including PVDF and PTFE. These materials provide chemical compatibility and filtration performance for gases and solvents. Specific pore sizes and detailed performance specifications should be confirmed with the manufacturer based on application requirements.
What makes 50 mm Critical Small Scale Filter Device unique?
Its uniqueness lies in the availability of chemically resistant PVDF and PTFE membranes tailored for small-scale venting and filtration needs. The 50 mm size supports integration into small-volume systems, providing critical filtration for gases and solvents with reliable membrane integrity and compatibility with biopharmaceutical process fluids.
How does 50 mm Critical Small Scale Filter Device integrate with other systems?
The device integrates with single-use and stainless steel systems via standard sanitary connections, facilitating installation in small-scale bioprocess setups. It can be combined with upstream components like sanitary clamps and lab stands for secure mounting and downstream monitoring devices to ensure process control and filtration integrity.
Is 50 mm Critical Small Scale Filter Device suitable for regulated biopharmaceutical manufacturing?
Yes, the device is designed to meet the stringent requirements of regulated biopharmaceutical manufacturing. Its materials and construction support sterile filtration and venting applications, complying with industry standards for single-use systems and critical filtration components used in GMP environments.
Can 50 mm Critical Small Scale Filter Device be customized?
Customization options may be available depending on membrane material, pore size, and device configuration to meet specific process requirements. Customers should consult with the manufacturer to specify membrane type, housing design, and connection interfaces to ensure compatibility with their unique bioprocess workflows.
What other products are commonly used with 50 mm Critical Small Scale Filter Device?
Common complementary products include upstream components such as UltraClamp™ Sanitary Clamps and Universal Lab Stand for secure installation. Downstream, the device pairs with monitoring components like the SGT (Single-Use Gauge Tee). Additionally, support accessories such as the Stainless Steel Stand for FlexFill® Biocontainers are used in adjacent workflow stages.
